Research


The Memory and Cognition Laboratory investigates human cognitive functions focusing on memory processes. 

The goal of our research is to elucidate the brain-wide mechanism of memory processes including learning, consolidation, retrieval, and reconsolidation, and apply the fundamental knowledge to the development of therapeutic interventions for memory-related mental disorders. 

For this, we pursue the following aims:

1) Elucidate neural representations of memory traces across the brain regions, compared to the representations during actual experience (or perception).

2) Determine reorganization of memory traces throughout consolidation and reconsolidation.

3) Develop models for decoding of individual memory traces based on the neural activity patterns.

4) Develop effective interventions to treat disorders such as Post Traumatic Stress Disorder (PTSD) by manipulating target memory traces.


We use a number of methods including functional neuroimaging (fMRI) and brain stimulation (TMS) combined with behavioral approaches in human subjects.




Research




Research Area

1) Neural representations of memory traces
Memory processes allow humans to store newly learned information and retrieve that information later. Then, how are the memory traces represented in the brain? How does the representation in the brain compare between memory retrieval and actual experience? Can we decode individual memory traces from the neural activity patterns? To address these questions, we use behavioral approaches and functional neuroimaging with various multivariate pattern analyses.
 
2) Manipulating memories
Newly developed memories become stable through a consolidation process, during which the memory is in a labile or malleable state. Accumulated evidence demonstrates that even after this initial consolidation, stable memories also become labile again immediately following memory retrieval, requiring reconsolidation. Understanding this state is thought to hold great hope for providing a way to manipulate memories. We especially focus on determining the optimal condition for memory reconsolidation or reorganization, and developing efficient methods for manipulating target memory traces.

3) Interventions for treatment of Post Traumatic Stress Disorder (PTSD)
Emotional context during the initial experience of an event influences the processes of memory encoding and the early stages of consolidation. We investigate how negative emotion affect multiple memory processes, and develop therapeutic interventions for mental disorders such as PTSD, by providing tools for selective removing of negative emotion from traumatic memory.
 




기억인지연구실은 인간의 인지기능 중 기억과정에 중점을 두고 연구를 진행하고 있다본 연구실의 목표는 뇌전반에 걸친 기억과정(학습공고화인출재공고화 등을 포함)을 이해하고 그 원리를 바탕으로 효과적인 기억관련 정신장애 치료 방법을 개발하는 것이다이를 위해 본 연구실의 연구는, 1) 실제적인 경험(또는 지각)과 비교하여 뇌의 각 영역에서 기억이 표현되는 원리, 2) 공고화와 재공고화 과정에서 기억이 재구성되는 원리를 밝히며, 3) 신경활성패턴을 바탕으로 각각의 기억 정보를 디코딩하는 모델 개발과, 4) 특정 대상 기억을 조정하여 외상후스트레스장애와 같은 정신장애를 효과적으로 치료할 수 있는 방법 개발에 중점을 두고 있다. 주로 신경영상법(fMRI)과 뇌자극법(TMS)을 행동실험과 같이 사용하여 연구를 진행하고 있다.